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Tuesday, 10 January 2017

High efficiency CRISPR is coming soon after CRISPR-Cas9 revolutionized

CRISPR-Cas9 mediated genome editing (Image: GeneCopoeia)

CRISPR system that has revolutionized as the modern gene editing tool is now much more simple and compact. Scientists from UC Berkeley made a simpler re-engineered system that is more compact so that it can easily insert into cells for DNA editing.

In CRISPR-Cas9 system the Cas protein act as scissors which severs the double stranded DNA when targeted to a specific sequence of DNA. The new discovered system can double the efficiency of CRISPR-Cas9 system that can be potentially be useful for laboratory based experiments.

“The important thing here is that we found some of these CRISPR systems in a major branch of the bacterial tree, opening the door to a whole new world of microbes that are not cultured in the lab, so we don’t really know what they are and what their habits are,” said co-author Jennifer Doudna, a UC Berkeley professor of molecular and cell biology and of chemistry and a Howard Hughes Medical Institute investigator.

The same team also know to find the first CRISPR-Cas9 system in world’s smallest microbes which is equivalent to nanoscale member archaea.

Additionally they also identified two new CRISPR proteins CasY and CasX. The research was published in the journal Nature.

Further Reading: Berkeley News


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