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Thursday, 15 December 2016

A Potential Medicinal Plant Extract Proved to be Richly Effective on Multiple Pathogenic Bacteria Including Acinetobacter baumanii

Dr. Emad M. Abdallah
Roselle is a perennial or annual herb mostly grown in Africawhich is used as vegetable, beverage and also as herbal medicine. Two researches that were published in early 2016 in the Journal of Intercultural Ethnopharmacology and Journal of Acute Disease revealed that this plant extract has high anti-microbial activity effective also on multi-drug resistant microbes.

"Roselle or Hibiscus sabdariffa L. is a well known multipurpose tropical medicinal plant, this plant is intensively cultivated in Sudan and considered as one of the most famous non-alcoholic Sudanese beverage, known locally as “Karkadeh”, said Dr. Emad M. Abdallah, associate professor in bacteriology at College of Science and Arts at Al-Rass, Qassim University, Saudi Arabia;He is also the sole lead author of the study as reported to We The Microbiologist. He said further that "The macerate of the red calyces of this plant consumed as hot or cold drinks are also used in Sudanese folk medicine for the treatment of respiratory tract infections, colds, fever and hypertension. It is also mixed with other plants to treat malaria."

Dr. Abdallah treated the Calyces of Hibiscus sabrdariffa with methanol (Which collect polar and non-polar compoundsin orderto get the methanol extract) and then subjected different bacterial strains to it using disc diffusion tests. The bacteria taken for the study are both from gram- positive and gram-negative groups. The result shows larger zone of inhibition as compared to Gentamicin and Penicillin.
Larger zone of inhibition is observed with methanol extract of Hibiscus sabdariffa than Gentamicin and Penicillin
(Image: Dr. Emad Abdallah)

For further investigation about its role on Acinetobacter baumannii which is an opportunistic pathogen commonly seen in hospital acquired infections."The results revealed that the methanol extract of the calyces of Roselle has potent antibacterial activity against all tested bacteria (gram-negative and gram-positive), as well as multi-drug resistant Acinetobacter baumannii" said Dr. Abdallah.

"The results of the current study support the widespread use of this popular plant in Sudanese folk medicine, particularly against some illnesses related to microbial infections. The output of this investigation also introduces the calyces of Hibiscus sabdariffa as one of the most promising sources for new natural and effective antibacterial drugs competitor to antibiotics."

Multidrug resistance bacteria have been known to impose threats which allow researchers to come out with new convention of solution to eradicate such bacteria.  In his word, "The world witness a dramatic increase in the multi-drug resistant pathogens and on the other side there is an obvious failure of antibiotics to eradicate these pathogens. Such study, Support the opinion that it is worthy for the research scholars and pharmaceutical companies to carry out further investigations on natural products and medicinal plants for isolation and identification of new antibacterial compounds which can be formulated as effective antibiotics. Hibiscus sabdariffa could be extensively investigated for separating this bioactive compound and used as a new antimicrobial drug or used with the ineffective antibiotics in a synergy form to strengthen and alter the mode of action of the regular antibiotics against the antibiotics resistant bacteria."

Currently is looking to isolate single or group of compounds with added Microbiological, Pharmacological and Toxicological properties to innovate new bacterial drug from Hibiscus sabdariffa.



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