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Wednesday, 19 October 2016

Dual Research explains How Gut Bacteria can Protect against Harmful Invading Microbe

The researchers performed experiments in C. elegans worms infected with Salmonella bacteria. In this cross section of a worm, the rod-shaped microbes have invaded the animal's intestine, highlighted in purple. Credit: The Rockefeller University Source: Medical Express

Antibiotics have been saving millions of lives but the growing problem of antibiotic resistance now reflecting its downside; on the other side probiotics which are beneficial microorganisms which provides benefits of antibiotics avoiding any pitfalls. The mechanism of such probiotics is still poorly understood. A research that published in the journals Science and Immunology by researchers at The Rockefeller University pointed out the factual answer.

Their study explains how the enzymes produced by intestinal bacteria protect us from the gut worms and their harmful invasions. These findings together can open an opportunity to develop probiotics that can be used against harmful bacteria like Clostridium difficile.

Researchers in Science paper set out to investigate about the probiotic potential of Enterococcus faecium in the study model roundworm Caenorhabdis elegans. E. faecium has long been known to be a probiotic for livestock but their mode of action was still a smudge. In a series of experiments proved that E. faecium inhibits the harmful effects of infection by Salmonella typhimurium. It can able to grow but not causing tissue damage to the worms.

Additionally a protein called SagA produced by E. faecium is able to protect the worm and mice from Salmonella.

On the other paper of Science Immunology, researchers not only explained how E. faecium protected mice from S. typhimurium but also demonstrated how E. faecium prevented the pathogen to bypass the intestinall epithelium to attack other organs like Liver.

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