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Tuesday, 2 August 2016

Pricking new antibiotic from nose microbe

Like our gut our nose is also an ambush for microorganisms, where gut is flooded with food but nose is a wasteland. Resources are scare but competition is fierce and so nasal microbes fight with each other and kill with specific antibiotics. May be from those killers we might recruit useful weapons.

Researchers from University of Tübingen have found such a weapon or chemical drug called lugdunin. It is produced by the bacterium that already dwelling in our noses and able to kill microbes like Staphylococcus aureus. It is chemically unrelated to previous known antibiotics and hence we can welcome a new member in antibiotic family.

“It is the founding member of a new class of antimicrobial compounds,” says Andreas Peschel, who led the study.

Scientists look at this new chemical and might take years from now to launch it as clinical drug after it follows multiple tests. A new antibiotic is almost a new regiment always required to defeat antibiotic resistance in many bacteria.

Our body has different ecosystem considering bacterial adaptation. Looking at nose which is nutrient depriving and much competitive for bacterial survival, so it was obvious to see bacteria using their weapons to bring down others. One amongst such was Staphylococcus lugdunensis from which lugdunin was isolated. The chemical has an unusual structure and its mode of killing is still a smudge.
In relatively low concentrations it was found promising to kill drug resistance S. aureus and Enterococcus, and also number of other disease causing bacteria.

Source: The Atlantic


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