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Tuesday, 23 August 2016

Fusobacteria use a protein to bind colorectal tumor

A commonly found mouth bacteria called fusobacteria stick to developing colorectal polyps and cancer with the help of a sugar-binding protein. This a new research published from Harvard T.H. Chan School of Public Health and Hebrew University brought close to fight colon cancer. Garrett Lab at Harvard Chan School has already shown previously how fusobacteria worsen colorectal cancer but this is the first time they demonstrate how they stick to such developing tumors.

Wendy Garrett, co-senior study author added that it can provide ways to block the binding of fusobacteria to colorectal tumors. She added, “Alternatively, and perhaps more importantly, our findings suggest that drugs targeting the same or similar mechanisms of bacterial sugar-binding proteins could potentially prevent these bacteria from exacerbating colorectal cancer.”

The research was published in the journal Cell Host and Microbe on August 10, 2016.

Colorectal Cancer is the third leading cause of death in US. Epidemiology in 2012 has shown 1.4million cases and almost 694,000 deaths in the world. The microbes have significantly taking part worsening the condition of cancer, where fusobacteria is one of them.

The mechanism of the study was understood with human samples and mouse models by Garrett and co-author Gilad Bachrach of Hebrew University.



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