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Tuesday, 23 February 2016

New RNA modification may open new gates of Epigenetics

Is DNA to RNA to Protein then end? In a new research published in the journal Nature where researchers from Tel Aviv University, Sheba Medical Center and University of Chicago identifies the RNA which act as DNA template for Protein synthesis is associate with an extra letter and the same is a key regulator in gene regulation.

Epigenetics is the key regulation of gene regulation until recently known finding provided the central pivot of epigenetics. The modifications of the gene have an enormous impact in every biological process. RNA is found to have ten times higher modification than that of DNA. Besides one dimensional function of DNA as encoding genetic information, RNA whereas has wide variety of functions including catalytic, structural, regulatory activities and also storing genetic information.

The new modification of such class is methylation of position 1 of Adenosine (m1A). This modification was shown to be positioned in a telltale at the start of protein translation that is linked to protein synthesis. Not singularly but thousands of genes are associated with this modification that allow cells to regulate the expression of proteins needed for key biological processes.

Journal Source: Dan Dominissini, Sigrid Nachtergaele, Sharon Moshitch-Moshkovitz, Eyal Peer, Nitzan Kol, Moshe Shay Ben-Haim, Qing Dai, Ayelet Di Segni, Mali Salmon-Divon, Wesley C. Clark, Guanqun Zheng, Tao Pan, Oz Solomon, Eran Eyal, Vera Hershkovitz, Dali Han, Louis C. Doré, Ninette Amariglio, Gideon Rechavi, Chuan He. The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA. Nature, 2016; DOI: 10.1038/nature16998


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