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Saturday, 27 February 2016

Groundbreaking discovery cures glioblastoma

Groundbreaking research after around 30years a discovery that leads to destroy the brain tumours called glioblastoma. In the first of medical history, pharmacy researchers from University of North Carolina at Chapel Hill turned the skin cells into cancer hunting stem cells. The research technique published in Nature communications rose the possibilities to fight brain cancer.

Reprogrammed stem cells (green) chase down and kill glioblastoma cells (pink), potentially offering a new and more effective treatment option for a disease that has not had any in more than 30 years. (Credit: UNC Eshelman School of Pharmacy)


The survival rate of glioblastoma is about 30 percent and it has become much difficult to treat. Surgically even though most of the tumours are removed, some does stay invasive and finally these remnants grow back. Most of the patients are reported to die in a year and an half during diagnosis.
The research team reprogrammed the skin cells called fibroblasts (that produce collagen and connective tissue) that able to be induced neural stem cells. I mouse model, these modified neural stem cells have innate ability to glide around the brain to kill any cancer cells. The team proved even that these stem cells can be engineered to produce tumour killing protein, thus giving a new blow on cancer treatment.

Depending on the type of tumour, the researchers can modulate the survival rate of mice 160 to 220 percent. Researchers now focus on human stem cells to provide new ways for developing anti-cancer drugs. This newest research represented the nurture of stem-cell technology that won Nobel Prize back in 2012.



Journal Source: Juli R. Bagó, Adolfo Alfonso-Pecchio, Onyi Okolie, Raluca Dumitru, Amanda Rinkenbaugh, Albert S. Baldwin, C. Ryan Miller, Scott T. Magness, Shawn D. Hingtgen. Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma. Nature Communications, 2016; 7: 10593 DOI: 10.1038/ncomms10593
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