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Wednesday, 29 November 2017

Microbiome – You Need to Work for Yours.

A lot of people do not know that you can actually change what lives in your gut? The gut microbiome consists of the community of trillions of bacteria living in the digestive tract. In fact, 80% of your immune system is in your microbiome, which affects just about every process, including digestion, thinking clearly and maintaining a healthy weight.
However, when we think of the slow changes and timely adjustments to change our eating habits, our weight, our sleep patterns, and more that usually take months to benefit from, most would assume that changing the microbiome in the gut would be just another time-consuming dedicated process. This is not really so. The average lifespan of a bacterium in our microbiome is 20 minutes! So you have the opportunity every time you eat to begin to change the population of your gut microbiome.
There are several factors that contribute to a healthy gut microbiome, including environment, exercise, sleep, and stress. But the number one factor that determines what microbes live in our gut (and which ones die off) is our diet. By supporting your microbiome with the foods that are healthy for you, the microbiota living in your gut will get better at absorbing and processing nutrients that can affect weight loss, digestion and overall health.

Adapted from Jennifer Ellis

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Sunday, 26 November 2017

Survival strategies of bacteria in oxygen deprived environment.

Bacteria are known to exit in colonies, called biofilms, which enable them to live in harsh conditions and to resist antibiotics efficiently. One such bacterial species known to survive as biofilms and thrive in oxygen deprived environment is Pseudomonas aeruginosa.  They are the leading cause of death for people suffering from cystic fibrosis. The bacteria are known to adopt several strategies for subsistence in oxygen-less environment. They produce molecules known as phenazines that help them shuttle electrons from inside to outside of the cell  to the oxygen available at a distance. Another strategy is to make alternative versions of terminal oxidases (enzymes that transport electrons to oxygen) in low oxygen concentration conditions.

Jeanyong Jo and his team from the University of Columbia and with funding from the National Institute of Health have found that a part of the terminal oxidase, called the CcoN4 protein, help the bacteria to thrive well in low oxygen environment and to make them resistant to antibiotics as well.They have also found that this protein plays a major role in optimal utilization of the phenazines.

These findings would greatly enhance the developmental strategies for the therapy against the bacteria as these pathways are responsible for its survival as well as virulence. The study has been published in journal eLife.

For more information read here
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Thursday, 23 November 2017

A Breakthrough in Antibiotic resistance.

Antibiotic resistance, as discussed earlier, is one of the major health concerns. It has created a worrisome situation as patients are increasingly falling to its trap. Researches are constantly working in finding a solution to this problem. One such breakthrough has been achieved by a team of researchers of the Department of Biochemistry and Molecular Medicine at the Universitae de Montreal. The study by Bastein Casu, Tarun Arya, Benoite Bessette and Christian Baron.

Plasmid transfer is one the methods of gene transfer between bacterial species and these plasmids often carry genes for antibiotic resistance. The team at the Universitae de Montreal have come up with a novel approach to block the transfer of these genes. TraE protein is essential for gene transfer via plasmids. Learning about the proteins configuration the team have designed some molecules that when bind to this protein site hinders the gene transfer.

For complete story click Here
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Tuesday, 21 November 2017

The epicenter of Ebola outbreak unveils the mystery game of the virus.

In 2014 the Western African countries like Sierra Leone, Guinea and Liberia witnessed the worst Ebola virus epidemic of their history which brought the life there at a complete halt. The outbreak left 11,310 dead and approximately 17000 survivors of the disease, of whom many are suffering from post-Ebola syndrome,  requiring first-grade medical attention.

There is saying that goes every problem has a solution and that solution revolves around the problem itself. The only effort that is required is to recognize the hidden clues and keep going ahead. Something similar seems to happen in Sierra Leone, one of the outbreak centers. The scientific team led by Yoshihiro Kawaoka of the University of Wisconsin-Madison collected the blood samples of the  deceased, disease survivors and healthy individuals who have not come in contact with virus. After thorough analysis and extensive research the team found that the level of two biomarkers- L-threonine (an amino acid) and vitamin-D binding protein are the deciding factors of a patient's survival. A complete understanding of these two factors would open doors for drug development of this deadly virus.

For complete story read here
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Monday, 20 November 2017

Eureka moment- Repurposing of Chloroquine surfaced a new pathway to treat Zika virus.

Few days back We The Microbiologist had published a news update on drug repurposing. After paving a way to fight antibiotic resistance this method of drug testing has a another victory in line. This time the researchers at the Sanford Burnham Prebys Medical Discovery Institute and UC San Diego Institute of Medicine have found the anti-malaria drug Chloroquine to greatly eliminate the Zika virus effect in mice. For more details click here
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Saturday, 18 November 2017

The Fixed Dose regimen drive to treat TB in India by the Heath Ministry.

Recently on October 31st the Union Health Ministry of India has rolled out the FIXED DOSE REGIMEN to treat tuberculosis. According to the new methodology the TB patients will be given fixed doses of three-four drugs in a single pill on daily basis, dosage being based on the weight of the patient. The new treatment is promised to be effective and also it will reduce the pill burden.

Read here
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Friday, 17 November 2017

Another pandemic in row!

Recently the eastern African city if Madagascar is witnessing the dreaded plague outbreak that has claimed nearly 171 lives so far as per the official statistics. Health experts have said it to be 'worst outbreak in 50 years' and the condition will further worsen if the causal bacterial species Yersinia pestis becomes antibiotic resistant and spreads to nearby countries.  For complete report read  here
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